Bengaluru start-up develops artificial liver tissues

3D printed living tissues enable affordable medical research with reduced animal and human trials, and may eventually lead to full scale transplantable organs

Pandorum Technologies, a Bengaluru-based biotech start-up working on tissue engineering, announced that it has developed artificial tissue that performs the functions of the human liver. These 3D printed living tissues enable affordable medical research with reduced animal and human trials, and will eventually lead to full scale transplantable organs.

“This is a significant milestone. Being able to engineer complex tissues such as the human liver is no easy task,” said Dr Tuhin Bhowmick, Co-founder, Pandorum Technologies.”

“Development of artificial organs has numerous clinical uses. Cell-based organoids can be used to develop bio-artificial liver support systems for preserving life in patients who have developed liver failure. In the near future, such bio-printed organs will address the acute shortage of human organs available for surgical transplantation,”added Dr Bhowmick.

Pandorum’s artificial liver tissues represent a major step towards on-demand manufacturing of human organs for transplant, it can also play a significant role in developing new medicines and vaccines.

“Liver toxicity and drug metabolism are the key hurdles, and contributors to failed human trials. Our 3D bio-printed mini-livers that mimic the human liver will serve as test platforms for discovery and development of drugs with better efficacy, less side-effects and at lower costs,” said Arun Chandru, Co-founder and MD, Pandorum Technologies.

“Yes, it is a multi-billion dollar fast growing market, and we intend to continue being a leader. More importantly, our technology has the potential to impact millions of lives,” added Chandru.

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